Vectors and 3D Models
Local Search - Health
Weather Information
Get the App for Smartphones and Tablets

Go Back


WhmSoft Free Articles Directory
Free Articles for Reprint
Free Articles to Publish
Free Articles for Newsletters
Videos to Watch


Page Generation Date and Time:
04/26/2017 09:54:44

 
Free the Animation VR
Play to reveal 3D images and 3D models!
VR Icon  
 
vlrPhone / vlrFilter
Project of very low consumption, radiation and bitrate softphones, with the support of the spatial audio, of the frequency shifts and of the ultrasonic communications / Multifunction Audio Filter with Remote Control!



 
 
Alexa Data
 

Go To Articles Directory Home Page

To get the current article, - See Below (at the bottom of the page) -.
For top news titles, see below.
Web sites and videos listed in this page are frequently updated.
If you find that this page is useful (quality of web sites, images and videos, ...), you can add it to your favorites.
Bookmark Page !

Tell a Friend:



With your mobile phone (WAP / I-Mode / iPhone / PDA), for free:
The Top News - http://www.whmsoft.net/services/wap/news.php
The Daily Files - http://www.whmsoft.net/services/wap/get.php
All the Directory Files - http://www.whmsoft.net/services/wap/choose.php

Web version of feeds:
Podcast Music - http://www.whmsoft.net/services/web/wpodcast.php
Daily Files - http://www.whmsoft.net/services/web/wget.php

You can play the Guitar Drum Revolution game (flash game) by following the link below:
Play Guitar Drum Revolution Game


You can play free online games (flash games) by following the link below:
Free Online Games

Play the samples below:
Ewoks AnnihilationBubble Bobble FlashPharaohs TombSevenTurtix

You can view the people (celebrities) news and the front page news (with videos, images and constant updates) by following the link below:
View Recent News
or by visiting the WhmSoft Service blog:
News Photos Slideshows


Article Keyword Videos to Watch
Health
Click on the image to start the video.



Related Topics
Images - Links - Articles

healthy snacks
healthy recipes
health insurance
healthy breakfast
health partners
health net
health equity
healthy dinner recipes
healthgrades
healthy meals
London healthy snacks
London


Related Images



Article Category Videos to Watch
Health
Go to the Videos Pages


Major Discovery: How Carcinogens Cause Cancer

The current belief in medical research holds that most cancers are caused by exposure to carcinogens, and that carcinogens cause cancer by damaging DNA. However, the huge effort and billions of dollars invested by the NIH, private foundations, and pharmaceutical companies in searching for damaged DNA in cancer has produced few discoveries and little benefits to the public. The reason for this limited success is very simple. The cause of most cancers is not damaged DNA.

Hunting for Genetic Mutations and Cancer
A little background:
1. What is a gene? A gene is an assembly line that produces a protein. A gene is made out of DNA.
2. What are proteins? Proteins are the major building blocks of cells.
3. What is a mutated gene? A mutated gene is a modified assembly line. A modification can take many forms, such as removing an essential part of the assembly line, replacing an important part with junk, etc. Very rarely a mutation is beneficial to the organism (X-Men, Evolution, Lance Armstrong?). In all other cases, a mutated gene is considered damaged DNA.

Current belief:
What is the cause of cancer? The word cause has two meanings. The first refers to the elements in the environment which impact our body, for instance, tobacco, x-ray radiation, asbestos, other chemicals, etc. These elements are called carcinogens. Today, hundreds of substances are classified as carcinogens. The other meaning of the word cause refers to the internal element of the body, which is the first to collapse under the attack of the carcinogens. Let's call this element our "Achilles heel."

The current belief in medical research holds that most cancers are caused by exposure to carcinogens, and that carcinogens cause cancer by mutating genes. In other words, according to the current belief, the structural integrity of our genes is our Achilles heel, and therefore, the first internal element to collapse under the attack of the carcinogens. This belief is so ingrained that the National Human Genome Research Institute (NHGRI), an institute at the NIH, recently stated that "all cancers are based on genetic mutations in body cells." Moreover, a search on PubMed, the search engine for scientific papers in life science, with the keywords "Mutation" AND "cancer" produced 86,490 papers and 12,238 reviews. Mutation hunting is also a big business. Look at the NIH budget allocated to discoveries of genetic mutations, the number of biotech companies chasing genetic mutations, the magnitude of the licensing agreements between biotech and pharmaceutical companies aimed to utilize newly discovered genetic mutations, and the number of stories in the media on genetic mutations and their so-called "link" to disease. However, this huge effort and billions of dollars has produced few discoveries and little benefits to the public. The reason for this limited success is simple. The cause of most cancers is not a genetic mutation. Our Achilles heel is not the structural integrity of our genes.

The story of the BRCA1 gene is a typical example of mutation hunting.

The Mystery of BRCA1
Genes, in general, produce proteins, which are the building blocks of cells. The concentration of proteins is tightly regulated. A mutated or physically altered gene produces an abnormal concentration of its protein, which may lead to disease. In 1994, Mark Skolnick, PhD, discovered the BRCA1 gene (BRCA1 is short for BReast CAncer 1). Following the discovery, scientists observed an abnormally low level of the BRCA1 protein in breast cancer tissues. The BRCA1 protein is a cell cycle suppressor, which means that the protein prevents cell replication. This observation created a lot of excitement. At the time, scientists believed that they were on the verge of finding the cause of breast cancer. The reasoning was that breast cancer patients must have a mutated BRCA1 gene, that is, a defected BRCA1 assembly line, which would explain the decreased production of the protein, and the excessive replication of breast cancer cells in tumors.

In the United States, 180,000 cases of breast cancer are diagnosed each year. However, the BRCA1 gene is mutated in less than 5% of these cases. In more than 95% of breast cancer patients the gene is not mutated, the assembly line is not defected.

So here is the mystery. If the gene is not mutated in the great majority of the breast cancer patients, why are the tumors showing low levels of the BRCA1 protein? Today, this is one of the biggest mysteries in cancer research.

The BRCA1 gene is not unique. Many normal (perfect shape, non-mutated) genes exhibit a mysterious abnormal (increased or decreased) production of proteins in cancer. Moreover, studies also report abnormal gene expression of normal genes in other diseases, such as atherosclerosis, obesity, osteoarthritis, type II diabetes, alopecia, type I diabetes, multiple sclerosis, asthma, lupus, thyroiditis, inflammatory bowel disease, rheumatoid arthritis, psoriasis, atopic dermatitis, and graft versus host disease.

According to Dr. Raxit J. Jariwalla in his European Journal of Cancer paper: (Jariwalla RJ. Microcompetition and the origin of cancer. Eur J Cancer. 2005 Jan;41(1):15-9): "The prevalent view of the nature of cancer holds that it is a complex genetic process resulting from the progressive accumulation of mutations in specific cellular genes, such as proto-oncogenes or tumor-suppressor genes, leading to perturbations in processes involving signal transduction, cell cycle regulation, and/or apoptosis. Genetic instability in tumors has been known for decades, however, the role of genomic instability in causing and promoting tumor growth remains controversial. Furthermore, although many studies report abnormal gene expression in cancer cells, often, no mutations or chemical modifications are observed around the locus of the dysregulated gene(s), suggesting that a genetic alteration is not the initiating event of cancer."

So, if a genetic alteration (also called genetic mutation or damaged DNA) is not the initiating event of most cancers, what is this event? And how do carcinogens produce this initiating event? You can find the answers to these questions at http://www.causeofcancer.org/


About the Author: John S. Boyd, Ph.D.
The Center for the Biology of Chronic Disease (see http://www.cbcd.net/), and causeofcancer.org (see http://www.causeofcancer.org/), Rochester, NY. We are a 501(c)3 not-for-profit organization that specializes in researching the biology of chronic disease. By "the biology of chronic disease" we mean the original disruption that causes the disease, and the sequence of events that lead from the original disruption to the development of clinical symptoms. We hope that once the biology is clear, pharmaceutical and biotech companies will be able to formulate drugs that reverse the effects of the disruption, and therefore cure the disease, or even block the original disruption, and therefore prevent the disease from developing in healthy individuals.




Recommended Web Site(s):

Easy Articles Home Page - Articles Directory

Recommended WhmSoft Web Sites, Feeds and WAP Address:

WhmSoft Software Home Page - Software
WhmSoft Services Login Page - Music and Images
WhmSoft Moblog Home Page - Blog - Photo Gallery
WhmSoft Free Online Games Home Page - Flash Games
WhmSoft Services RSS Feed - Daily Music, Image and 3D Flash Animation
Classical Music with Drum RSS Feed - MIDI and MP3 Files
Classical Music with Drum Podcast Feed - MP3 and MP3 Files
WAP / I-Mode / PDAs - Daily Music, Image and Flash Animation

Home Pages:

WhmSoft Free Articles for Reprint Home Page
WhmSoft Services Home Page - Music and Images
Copyright (C) 2006-2017 WhmSoft - All Rights Reserved.