Vectors and 3D Models
Local Search - Health
Weather Information
Get the App for Smartphones and Tablets

Go Back


WhmSoft Free Articles Directory
Free Articles for Reprint
Free Articles to Publish
Free Articles for Newsletters
Videos to Watch


Page Generation Date and Time:
09/26/2017 09:27:59

 
Free the Animation VR / AR
Play to reveal 3D images and 3D models!
   
 
vlrPhone / vlrFilter
Project of very low consumption, radiation and bitrate softphones, with the support of the spatial audio, of the frequency shifts and of the ultrasonic communications / Multifunction Audio Filter with Remote Control!



 
 
Alexa Data
 

Go To Articles Directory Home Page

To get the current article, - See Below (at the bottom of the page) -.
For top news titles, see below.
Web sites and videos listed in this page are frequently updated.
If you find that this page is useful (quality of web sites, images and videos, ...), you can add it to your favorites.
Bookmark Page !

Tell a Friend:



With your mobile phone (WAP / I-Mode / iPhone / PDA), for free:
The Top News - http://www.whmsoft.net/services/wap/news.php
The Daily Files - http://www.whmsoft.net/services/wap/get.php
All the Directory Files - http://www.whmsoft.net/services/wap/choose.php

Web version of feeds:
Podcast Music - http://www.whmsoft.net/services/web/wpodcast.php
Daily Files - http://www.whmsoft.net/services/web/wget.php

You can play the Guitar Drum Revolution game (flash game) by following the link below:
Play Guitar Drum Revolution Game


You can play free online games (flash games) by following the link below:
Free Online Games

Play the samples below:
01306 Zowie00037 Shanghai Dynasty1303 Lance La HacheAgent KSnowy Treasure Hunter 3

You can view the people (celebrities) news and the front page news (with videos, images and constant updates) by following the link below:
View Recent News
or by visiting the WhmSoft Service blog:
News Photos Slideshows


Article Keyword Videos to Watch
Health
Click on the image to start the video.



Related Topics
Images - Links - Articles

New York


Related Images



Article Category Videos to Watch
Health
Go to the Videos Pages


Trichothiodystrophy

Trichothiodystrophy or TTD, as it is concisely mentioned, is a heterogeneous group of autosomal recessive disorders, characterized by abnormally sulfur deficient brittle hair and accompanied by ichthyosis and other manifestations. In TTD patients, the hair appear dry, short and sparse, and the ones already existing splits longitudinally in to small fibers, the viscoelastic parameters of hair being compromised compared to controls.

Inside the range of TTD syndrome are numerous interrelated neuroectodermal disorders. The Trichothiodystrophy syndromes are invariably characterized by the defective synthesis of high-sulfur matrix proteins. Half of the patients show abnormalities in nucleotide excision repair (NER) of ultraviolet damaged DNA.

In fact, three categories are recognized on the basis of cellular responses to UV damage and the affected gene. Most patients show mutations on the two alleles of the XPD gene. In UV-sensitive TTD patients, the TFIIH transcription factor containing XPB and XPD helicase activities necessary for both transcription initiation and DNA repair are found to be damaged. Beyond deficiency in the NER pathway, basal transcription is altered leading to decreased transcription of specific genes.

TTD patients generally have an unusual facial appearance, marked by protruding ears and receding chin, and retarded overall growth. The growth retardation, neurological abnormalities and brittle hair and nails are attributed to the depressed RNA synthesis in TTD patients.

Light microscopy on TTD patients reveals trichosis of hair and an irregular hair surface and diameter. But a nodal appearance and decreased cuticular layer with twisting may be misleading and may closely mimic trichorrhexis nodosa. Also, when the patient’s hair is viewed under polarized light, it shows alternate light and dark bands giving a strand a ‘tiger-tail’ appearance. But it has been noticed recently that such ‘tiger-tail’ patterns are also found in healthy infants. Hence the amino acid analysis quantitating sulfur levels remains a reliable test for TTD.


About the Author: Get more information about rare disorders at www.rare-disorders.com




Recommended Web Site(s):

Easy Articles Home Page - Articles Directory

Recommended WhmSoft Web Sites, Feeds and WAP Address:

WhmSoft Software Home Page - Software
WhmSoft Services Login Page - Music and Images
WhmSoft Moblog Home Page - Blog - Photo Gallery
WhmSoft Free Online Games Home Page - Flash Games
WhmSoft Services RSS Feed - Daily Music, Image and 3D Flash Animation
Classical Music with Drum RSS Feed - MIDI and MP3 Files
Classical Music with Drum Podcast Feed - MP3 and MP3 Files
WAP / I-Mode / PDAs - Daily Music, Image and Flash Animation

Home Pages:

WhmSoft Free Articles for Reprint Home Page
WhmSoft Services Home Page - Music and Images
Copyright (C) 2006-2017 WhmSoft - All Rights Reserved.