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Disclosures about prevention and treatment of digestive bleeding ulcer
When it comes to treating peptic ulcer complicated by the presence of Helicobacter Pylori and stomach recurrent bleedings appears the question whether pharmacological procedures really work. Based on medical cases and highly researched evidences doctors prove the effects of endoscopical evaluation and treatment as well as of pharmaceutical management of upper gastrointestinal bleedings.
Scientists also tried to compare and demonstrate the efficiency of treatments with H2-blockers or the ones with Omeprazole.
Searching for cases of this nature we will surely find situations with lacks in therapy that we cannot use for our experiment. Cases without methodological mistakes must be analyzed from points of view of diagnosis, complication, secondary complaints, and randomization and double-blind methods.
In a first study, a group of 57 patients with peptic ulcer, visible blood vessels, profuse perspirations and adherent blood clots are subjected at random to a treatment with Ranitidine or Omeprazole both I.V. No blinding was used and patients didnít undergo endoscopical explorations. The results were: 8 of 30 patients treated with an inhibitor of proton-pump showed signs of rebleeding beside 10 of 24 treated with an H2-receptor antagonist.
The second study includes a number of about 200 people suffering from peptic ulcer with visible cots or bleedings. At chance they are subjected to Omeprazole or placebo. Results concluded: 35 of 100 subjects with placebo show clinical signs of rebleedings beside 6 of 105 treated with Omeprazole.
One third experiment shows 24%recurrence in patients with Omeprazole and 4% at those cured with Cimetidine after endoscopic sessions. All persons that submitted have been effectively treated by endoscopies and both substances were administered intravenous.
All the completed studies were made on patients mostly of Asia and it is not yet known whether results can be generalized for all populations on the planet. Also we donít surely know if oral and intravenous administration of the medications has the exact same final results.
The scientistsí report concluding these tests justify the use of proton-pomp inhibitors like Omeprazole for patients with peptic bleeding ulcer after endoscopical treatment. An approximately 44%, 28% and 22% of people showing improvements after this kind of cure encourage doctors to prescribe Omeprazole.
Minimal costs for a three day treatment and low efficiency of H2-receptor antagonists lead to the conclusion of at least momentarily best effectiveness of the medications in the same class with Omeprazole.
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